| Gene Information | |
|---|---|
| Gene Name | SLC43A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 559 |
| Protein Names | Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000149150 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75387 |
| Gene Card | SLC43A1 |
| Uniprot ID | O75387 |
| Pfam | PF07690 |
| In ASD | no |
| Allosteric Prediction | no (-1.003790107) |
| Ortholog in Animals | Alpaca_ SLC43A1 ( ortholog_one2one ) Dog_ SLC43A1 ( ortholog_one2one ) GuineaPig_ SLC43A1 ( ortholog_one2one ) Macaque_ SLC43A1 ( ortholog_one2one ) Mouse_ Slc43a1 ( ortholog_one2one ) Pig_ SLC43A1 ( ortholog_one2one ) Rat_ Slc43a1 ( ortholog_one2one ) Rabbit_ SLC43A1 ( ortholog_one2one ) |
| Ohnologs | SLC43A2 |
| Paralogs | SLC43A2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed in fetus and adult (PubMed:9722952). Highest expression in adult pancreas, liver, skeletal muscle (PubMed:9722952, PubMed:12930836). In fetus, highest expression in liver and lower levels in kidney, and lung (PubMed:12930836). Exclusively expressed in the glomeruli along the glomerular capillary walls (PubMed:19443642). {ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:19443642, ECO:0000269|PubMed:9722952}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17151933 rs34746107 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19443642}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642}. |
| Mouse PG classification | NA |
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