| Gene Information | |
|---|---|
| Gene Name | TFPI2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 235 |
| Protein Names | Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000105825 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48307 |
| Gene Card | TFPI2 |
| Uniprot ID | P48307 |
| Pfam | PF00014 |
| In ASD | no |
| Allosteric Prediction | no (-0.435239782) |
| Ortholog in Animals | Alpaca_ TFPI2 ( ortholog_one2one ) Dog_ TFPI2 ( ortholog_one2one ) GuineaPig_ TFPI2 ( ortholog_one2one ) Macaque_ TFPI2 ( ortholog_one2one ) Mouse_ Tfpi2 ( ortholog_one2one ) Pig_ TFPI2 ( ortholog_one2one ) Rat_ Tfpi2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SPINT4, EPPIN, WFIKKN1, KIAA0319, TFPI, SPINT1, AMBP, SPINT2, WFIKKN2, WFDC8, LRP11, KIAA0319L, WFDC6 |
| Tissue | placenta, adrenal.gland, greater.omentum, ovary, oviduct |
| Tissue Specificity | Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZR0 (X-ray 1.80A ) |
| DBSNP | rs1804202 rs12669450 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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