| Gene Information | |
|---|---|
| Gene Name | VPS45 |
| Organism | Homo sapiens (Human) |
| Gene Length | 570 |
| Protein Names | Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000136631 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NRW7 |
| Gene Card | VPS45 |
| Uniprot ID | Q9NRW7 |
| Pfam | PF00995 |
| In ASD | no |
| Allosteric Prediction | no (-0.987845305) |
| Ortholog in Animals | Alpaca_ VPS45 ( ortholog_one2one ) Dog_ VPS45 ( ortholog_one2one ) GuineaPig_ VPS45 ( ortholog_one2one ) Macaque_ VPS45 ( ortholog_one2one ) Mouse_ Vps45 ( ortholog_one2one ) Pig_ VPS45 ( ortholog_one2one ) Rat_ Vps45 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCFD2, VPS33A, STXBP3, STXBP2, VPS33B, SCFD1, STXBP1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expression was highest in testis, heart and brain, intermediate in kidney, spleen, prostate, ovary, small intestine and thymus and low in lung, skeletal muscle, placenta, colon, pancreas, peripheral blood leukocytes and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs879255237 rs782269909 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. {ECO:0000250}. |
| Mouse PG classification | NA |
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