Gene Information
Gene NamePARL
OrganismHomo sapiens (Human)
Gene Length379
Protein NamesPresenilins-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000175193 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H300
Gene CardPARL
Uniprot IDQ9H300
PfamPF01694
In ASDno
Allosteric Predictionno (-0.58977308)
Ortholog in AnimalsAlpaca_ PARL ( ortholog_one2one )
Dog_ PARL ( ortholog_one2one )
GuineaPig_ PARL ( ortholog_one2one )
Macaque_ PARL ( ortholog_one2one )
Mouse_ Parl ( ortholog_one2one )
Pig_ PARL ( ortholog_one2one )
Rat_ Parl ( ortholog_one2many )
OhnologsNA
ParalogsRHBDF2, RHBDL3, RHBDL1, RHBDL2, RHBDF1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs4912470  rs3732581 
Subcellular location [CC]Mitochondrion inner membrane {ECO:0000269|PubMed:17116872, ECO:0000269|PubMed:22354088};
Multi-pass membrane protein {ECO:0000269|PubMed:17116872}.;
[P-beta]: Nucleus {ECO:0000269|PubMed:17116872}. Note=Translocated into the nucleus by an unknown mechanism (PubMed:17116872). {ECO:0000269|PubMed:17116872}.
Mouse PG classificationNA
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