| Gene Information | |
|---|---|
| Gene Name | EPHA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1037 |
| Protein Names | Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7) |
| Target Name | ephrin type-a receptor 5 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000145242 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P54756 |
| Gene Card | EPHA5 |
| Uniprot ID | P54756 |
| Pfam | PF14575; PF01404; PF00041; PF07714; PF00536 |
| In ASD | no |
| Allosteric Prediction | yes (0.383680899) |
| Ortholog in Animals | Alpaca_ EPHA5 ( ortholog_one2one ) Dog_ EPHA5 ( ortholog_one2one ) Macaque_ EPHA5 ( ortholog_one2one ) Mouse_ Epha5 ( ortholog_one2one ) Pig_ EPHA5 ( ortholog_one2one ) Rat_ Epha5 ( ortholog_one2one ) Rabbit_ EPHA5 ( ortholog_one2one ) |
| Ohnologs | EPHA4, EPHA10 |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | brain |
| Tissue Specificity | Almost exclusively expressed in the nervous system in cortical neurons, cerebellar Purkinje cells and pyramidal neurons within the cortex and hippocampus. Display an increasing gradient of expression from the forebrain to hindbrain and spinal cord. {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2R2P (X-ray 2.40A ) 4ET7 (X-ray 2.60A ) |
| DBSNP | rs33932471 rs55710198 rs56205382 rs199614818 rs56074660 rs1057520012 rs36050417 rs56359290 rs56312931 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10375373}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P54757}. Cell projection, dendrite {ECO:0000269|PubMed:10375373, ECO:0000269|PubMed:9191074}. |
| Mouse PG classification | NA |
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