| Gene Information | |
|---|---|
| Gene Name | GABRB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1) |
| Target Name | gaba(a) receptor |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000163288 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P18505 |
| Gene Card | GABRB1 |
| Uniprot ID | P18505 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.258707548) |
| Ortholog in Animals | Alpaca_ GABRB1 ( ortholog_one2one ) GuineaPig_ GABRB1 ( ortholog_one2one ) Macaque_ GABRB1 ( ortholog_one2one ) Mouse_ Gabrb1 ( ortholog_one2one ) Pig_ GABRB1 ( ortholog_one2one ) Rat_ Gabrb1 ( ortholog_one2one ) |
| Ohnologs | GABRB2, GABRB3 |
| Paralogs | GABRB2, CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRA1, GLRB |
| Tissue | brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs886039817 rs886039818 rs41311286 rs17852014 |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P50571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. Cell membrane {ECO:0000269|PubMed:26950270}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P50571}. |
| Mouse PG classification | NA |
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