| Gene Information | |
|---|---|
| Gene Name | CD40 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) |
| Target Name | cd40l receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000101017 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P25942 |
| Gene Card | CD40 |
| Uniprot ID | P25942 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (0.553305203) |
| Ortholog in Animals | Alpaca_ CD40 ( ortholog_one2one ) Dog_ CD40 ( ortholog_one2one ) GuineaPig_ CD40 ( ortholog_one2one ) Macaque_ CD40 ( ortholog_one2one ) Mouse_ Cd40 ( ortholog_one2one ) Pig_ CD40 ( ortholog_one2one ) Rat_ Cd40 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | B-cells and in primary carcinomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1CZZ (X-ray 2.70A ) 1D00 (X-ray 2.00A ) 1FLL (X-ray 3.50A ) 1LB6 (X-ray 1.80A ) 3QD6 (X-ray 3.50A ) 5DMI (X-ray 3.69A ) 5DMJ (X-ray 2.79A ) 5IHL (X-ray 3.30A ) 6FAX (X-ray 2.99A ) 6PE8 (X-ray 2.84A ) 6PE9 (X-ray 3.13A ) 7P3I (X-ray 2.29A ) |
| DBSNP | rs750234130 rs28931586 rs11569321 rs11086998 |
| Subcellular location [CC] | [Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted. |
| Mouse PG classification | HPG |
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