| Gene Information | |
|---|---|
| Gene Name | HSPB5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 175 |
| Protein Names | Alpha-crystallin B chain (Alpha(B)-crystallin) (Heat shock protein beta-5) (HspB5) (Renal carcinoma antigen NY-REN-27) (Rosenthal fiber component) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P02511 |
| Gene Card | CRYAB |
| Uniprot ID | P02511 |
| Pfam | PF00525; PF00011 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). {ECO:0000269|PubMed:2387586, ECO:0000269|PubMed:28493373, ECO:0000269|PubMed:838078}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001657(Rat);0.025806(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2KLR (NMR - ) 2N0K (NMR - ) 2WJ7 (X-ray 2.63A ) 2Y1Y (X-ray 2.00A ) 2Y1Z (X-ray 2.50A ) 2Y22 (X-ray 3.70A ) 2YGD (EM 9.40A ) 3J07 (Other - ) 3L1G (X-ray 3.32A ) 3SGM (X-ray 1.70A ) 3SGN (X-ray 2.81A ) 3SGO (X-ray 2.56A ) 3SGP (X-ray 1.40A ) 3SGR (X-ray 2.17A ) 3SGS (X-ray 1.70A ) 4M5S (X-ray 1.37A ) 4M5T (X-ray 2.00A ) 5VVV (X-ray 2.80A ) 6BP9 (NMR - ) 7ROJ (X-ray 1.60A ) |
| DBSNP | rs2234703 rs2234704 rs139750142 rs1114167341 rs387907339 rs104894201 rs150516929 rs141638421 rs370803064 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:28493373}. Nucleus {ECO:0000269|PubMed:19464326}. Secreted {ECO:0000269|PubMed:32272059}. Lysosome {ECO:0000250|UniProtKB:P23927}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326). Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:19464326, ECO:0000269|PubMed:28493373, ECO:0000269|PubMed:32272059}. |
| Mouse PG classification | NA |
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