| Gene Information | |
|---|---|
| Gene Name | HSPB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 205 |
| Protein Names | Heat shock protein beta-1 (HspB1) (28 kDa heat shock protein) (Estrogen-regulated 24 kDa protein) (Heat shock 27 kDa protein) (HSP 27) (Stress-responsive protein 27) (SRP27) |
| Target Name | heat shock protein 20 |
| Target Type | Clinical trial target |
| Gene Age | 886 ( ENSG00000106211 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P04792 |
| Gene Card | HSPB1 |
| Uniprot ID | P04792 |
| Pfam | PF00011 |
| In ASD | no |
| Allosteric Prediction | yes (0.622382397) |
| Ortholog in Animals | Alpaca_ HSPB1 ( ortholog_one2one ) Dog_ HSPB1 ( ortholog_one2one ) GuineaPig_ HSPB1 ( ortholog_one2one ) Macaque_ HSPB1 ( ortholog_one2one ) Mouse_ Hspb1 ( ortholog_one2one ) Pig_ HSPB1 ( ortholog_one2one ) Rat_ Hspb1 ( ortholog_one2one ) Rabbit_ HSPB1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRYAB, CRYAA, HSPB3, HSPB6, HSPB2, HSPB8, HSPB7, HSPB9 |
| Tissue | NA |
| Tissue Specificity | Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. {ECO:0000269|PubMed:1560006}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001228(Rat);0.026316(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2N3J (NMR - ) 3Q9P (X-ray 2.00A ) 3Q9Q (X-ray 2.20A ) 4MJH (X-ray 2.60A ) 6DV5 (X-ray 3.58A ) 6GJH (X-ray 2.10A ) |
| DBSNP | rs1563651698 rs1554614432 rs557327165 rs1393404971 rs375244209 rs770272088 rs121909113 rs29001571 rs558882005 rs28939680 rs863225022 rs28939681 rs121909112 rs1554614650 rs28937568 rs374995963 rs1032400275 rs1422978230 rs28937569 rs774585320 rs772767500 rs764297134 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10777697, ECO:0000269|PubMed:28144995}. Nucleus {ECO:0000269|PubMed:19464326}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:10777697}. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000269|PubMed:19464326}. |
| Mouse PG classification | LPG |
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