| Gene Information | |
|---|---|
| Gene Name | HSPA8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 646 |
| Protein Names | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1) |
| Target Name | heat shock cognate 71 kda protein |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000109971 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P11142 |
| Gene Card | HSPA8 |
| Uniprot ID | P11142 |
| Pfam | PF00012 |
| In ASD | yes |
| Allosteric Prediction | yes (1.144813537) |
| Ortholog in Animals | Alpaca_ HSPA8 ( ortholog_one2one ) Dog_ HSPA8 ( ortholog_one2one ) GuineaPig_ HSPA8 ( ortholog_one2one ) Macaque_ HSPA8 ( ortholog_one2one ) Mouse_ Hspa8 ( ortholog_one2one ) Pig_ HSPA8 ( ortholog_one2one ) Rat_ AABR07011951.1 ( ortholog_one2one ) |
| Ohnologs | HSPA1B, HSPA1A, HSPA1L |
| Paralogs | HSPA4L, HSPA6, HSPA1L, HSPH1, HSPA2, HSPA1A, HSPA1B, HSPA9, HSPA13, HSPA5, HSPA14, HYOU1, HSPA4 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:11276205}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3AGY (X-ray 1.85A ) 3AGZ (X-ray 2.51A ) 3ESK (X-ray 2.05A ) 3FZF (X-ray 2.20A ) 3FZH (X-ray 2.00A ) 3FZK (X-ray 2.10A ) 3FZL (X-ray 2.20A ) 3FZM (X-ray 2.30A ) 3LDQ (X-ray 1.90A ) 3M3Z (X-ray 2.10A ) 4H5N (X-ray 1.86A ) 4H5R (X-ray 1.64A ) 4H5T (X-ray 1.90A ) 4H5V (X-ray 1.75A ) 4H5W (X-ray 1.94A ) 4HWI (X-ray 2.27A ) 4KBQ (X-ray 2.91A ) 5AQF (X-ray 1.88A ) 5AQG (X-ray 2.24A ) 5AQH (X-ray 2.00A ) 5AQI (X-ray 1.98A ) 5AQJ (X-ray 1.96A ) 5AQK (X-ray 2.09A ) 5AQL (X-ray 1.69A ) 5AQM (X-ray 1.63A ) 5AQN (X-ray 2.45A ) 5AQO (X-ray 2.12A ) 5AQP (X-ray 2.08A ) 5AQQ (X-ray 2.72A ) 5AQR (X-ray 1.91A ) 5AQS (X-ray 2.00A ) 5AQT (X-ray 1.90A ) 5AQU (X-ray 1.92A ) 5AQV (X-ray 1.75A ) 6B1I (X-ray 2.30A ) 6B1M (X-ray 1.90A ) 6B1N (X-ray 1.80A ) 6ZYJ (X-ray 1.85A ) |
| DBSNP | rs11551602 rs11551598 |
| Subcellular location [CC] | Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. |
| Mouse PG classification | NA |
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