| Gene Information | |
|---|---|
| Gene Name | HSPA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 654 |
| Protein Names | Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein) |
| Target Name | endoplasmic reticulum chaperone bip |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000044574 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P11021 |
| Gene Card | HSPA5 |
| Uniprot ID | P11021 |
| Pfam | PF00012 |
| In ASD | yes |
| Allosteric Prediction | yes (1.157832417) |
| Ortholog in Animals | Alpaca_ HSPA5 ( ortholog_one2one ) Dog_ HSPA5 ( ortholog_one2one ) Macaque_ HSPA5 ( ortholog_one2one ) Mouse_ Hspa5 ( ortholog_one2one ) Pig_ HSPA5 ( ortholog_one2one ) Rat_ Hspa5 ( ortholog_one2one ) Rabbit_ HSPA5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HSPA4L, HSPA6, HSPA1L, HSPH1, HSPA2, HSPA1A, HSPA1B, HSPA9, HSPA13, HSPA14, HSPA8, HYOU1, HSPA4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001680(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3IUC (X-ray 2.40A ) 3LDL (X-ray 2.30A ) 3LDN (X-ray 2.20A ) 3LDO (X-ray 1.95A ) 3LDP (X-ray 2.20A ) 5E84 (X-ray 2.99A ) 5E85 (X-ray 2.57A ) 5E86 (X-ray 2.68A ) 5EVZ (X-ray 1.85A ) 5EX5 (X-ray 1.90A ) 5EXW (X-ray 1.90A ) 5EY4 (X-ray 1.86A ) 5F0X (X-ray 1.60A ) 5F1X (X-ray 1.90A ) 5F2R (X-ray 2.15A ) 6ASY (X-ray 1.85A ) 6CZ1 (X-ray 1.68A ) 6DFM (X-ray 2.14A ) 6DFO (X-ray 2.54A ) 6DO2 (X-ray 1.70A ) 6DWS (X-ray 1.90A ) 6ZMD (X-ray 2.64A ) 7N1R (X-ray 2.03A ) |
| DBSNP | rs35356639 |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000269|PubMed:21080038, ECO:0000269|PubMed:21289099, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:29497057}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasm {ECO:0000250|UniProtKB:P20029}. Cell surface {ECO:0000269|PubMed:15098107, ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:27159390, ECO:0000269|PubMed:28053106, ECO:0000269|PubMed:33432092}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390). {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:20484814, ECO:0000269|PubMed:24355926, ECO:0000269|PubMed:27159390}. |
| Mouse PG classification | NA |
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