| Gene Information | |
|---|---|
| Gene Name | HSPA1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 641 |
| Protein Names | Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000204389 ) 3 ( ENSG00000215328 ) 3 ( ENSG00000234475 ) 3 ( ENSG00000235941 ) 3 ( ENSG00000237724 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P0DMV8 |
| Gene Card | HSPA1A |
| Uniprot ID | P0DMV8 |
| Pfam | PF00012 |
| In ASD | yes |
| Allosteric Prediction | yes (1.132506286) |
| Ortholog in Animals | Dog_ HSP70 ( ortholog_one2many ) Mouse_ Hspa1a ( ortholog_many2many ) Mouse_ Hspa1b ( ortholog_many2many ) |
| Ohnologs | HSPA8, HSPA2 |
| Paralogs | HSPA4L, HSPA6, HSPA1L, HSPH1, HSPA2, HSPA9, HSPA13, HSPA5, HSPA14, HSPA8, HYOU1, HSPA4, HSPA1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.012308(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HJO (X-ray 2.30A ) 1S3X (X-ray 1.84A ) 1XQS (X-ray 2.90A ) 2E88 (X-ray 1.80A ) 2E8A (X-ray 1.77A ) 2LMG (NMR - ) 3A8Y (X-ray 2.30A ) 3ATU (X-ray 1.65A ) 3ATV (X-ray 1.58A ) 3AY9 (X-ray 1.75A ) 3D2E (X-ray 2.35A ) 3D2F (X-ray 2.30A ) 3JXU (X-ray 2.14A ) 3LOF (X-ray 2.40A ) 3Q49 (X-ray 1.54A ) 4IO8 (X-ray 2.58A ) 4J8F (X-ray 2.70A ) 4PO2 (X-ray 2.00A ) 4WV5 (X-ray 2.04A ) 4WV7 (X-ray 2.42A ) 5AQW (X-ray 1.53A ) 5AQX (X-ray 2.12A ) 5AQY (X-ray 1.56A ) 5AQZ (X-ray 1.65A ) 5AR0 (X-ray 1.90A ) 5BN8 (X-ray 1.34A ) 5BN9 (X-ray 1.69A ) 5BPL (X-ray 1.93A ) 5BPM (X-ray 1.83A ) 5BPN (X-ray 2.10A ) 5GJJ (NMR - ) 5MKR (X-ray 1.87A ) 5MKS (X-ray 1.99A ) 5XI9 (NMR - ) 5XIR (NMR - ) 6FHK (X-ray 1.66A ) 6G3R (X-ray 1.40A ) 6G3S (X-ray 2.30A ) 6JPV (X-ray 2.15A ) 6K39 (X-ray 1.40A ) 6ZYI (X-ray 1.52A ) 7FGM (X-ray 2.20A ) 7KW7 (EM 3.57A ) 7Q4R (X-ray 1.79A ) |
| DBSNP | rs562047 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000269|PubMed:27137183}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27137183}. Secreted {ECO:0000250|UniProtKB:Q61696}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Mouse PG classification | NA |
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