| Gene Information | |
|---|---|
| Gene Name | HSP90B1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 803 |
| Protein Names | Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog) |
| Target Name | endoplasmin |
| Target Type | Clinical trial target |
| Gene Age | 36 ( ENSG00000166598 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P14625 |
| Gene Card | HSP90B1 |
| Uniprot ID | P14625 |
| Pfam | PF02518; PF00183 |
| In ASD | no |
| Allosteric Prediction | yes (1.147240181) |
| Ortholog in Animals | Alpaca_ HSP90B1 ( ortholog_one2one ) Dog_ HSP90B1 ( ortholog_one2one ) GuineaPig_ HSP90B1 ( ortholog_one2one ) Macaque_ HSP90B1 ( ortholog_one2one ) Mouse_ Hsp90b1 ( ortholog_one2one ) Pig_ HSP90B1 ( ortholog_one2one ) Rat_ Hsp90b1 ( ortholog_one2one ) Rabbit_ HSP90B1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRAP1, HSP90AA1, HSP90AB1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4NH9 (X-ray 2.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum lumen {ECO:0000305|PubMed:12475965}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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