| Gene Information | |
|---|---|
| Gene Name | PREX2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1606 |
| Protein Names | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000046889 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q70Z35 |
| Gene Card | PREX2 |
| Uniprot ID | Q70Z35 |
| Pfam | PF00610; PF00169; PF00621 |
| In ASD | no |
| Allosteric Prediction | no (-0.09765861) |
| Ortholog in Animals | Alpaca_ PREX2 ( ortholog_one2one ) Dog_ PREX2 ( ortholog_one2one ) GuineaPig_ PREX2 ( ortholog_one2one ) Macaque_ PREX2 ( ortholog_one2one ) Mouse_ Prex2 ( ortholog_one2one ) Pig_ PREX2 ( ortholog_one2one ) Rat_ Prex2 ( ortholog_one2one ) Rabbit_ PREX2 ( ortholog_one2one ) |
| Ohnologs | PREX1 |
| Paralogs | DEPTOR, PREX1, GPR155 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart. {ECO:0000269|PubMed:15304343}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6BNM (X-ray 1.90A ) |
| DBSNP | rs11784582 rs147538692 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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