| Gene Information | |
|---|---|
| Gene Name | HSP90AB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 724 |
| Protein Names | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) |
| Target Name | heat shock protein 90 beta |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000096384 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P08238 |
| Gene Card | HSP90AB1 |
| Uniprot ID | P08238 |
| Pfam | PF02518; PF00183 |
| In ASD | yes |
| Allosteric Prediction | yes (1.679701356) |
| Ortholog in Animals | Alpaca_ HSP90AB1 ( ortholog_one2one ) Dog_ HSP90AB1 ( ortholog_one2one ) GuineaPig_ HSP90AB1 ( ortholog_one2one ) Macaque_ HSP90AB1 ( ortholog_one2one ) Mouse_ Hsp90ab1 ( ortholog_one2one ) Pig_ HSP90AB1 ( ortholog_one2one ) Rat_ Hsp90ab1 ( ortholog_one2one ) Rabbit_ HSP90AB1 ( ortholog_one2many ) |
| Ohnologs | HSP90AA1, HSP90AB3P |
| Paralogs | HSP90AA1, HSP90B1, TRAP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1QZ2 (X-ray 3.00A ) 1UYM (X-ray 2.45A ) 2L6J (NMR - ) 3FWV (X-ray 2.20A ) 3NMQ (X-ray 2.20A ) 3PRY (X-ray 2.28A ) 3UQ3 (X-ray 2.60A ) 5FWK (EM 3.90A ) 5FWL (EM 9.00A ) 5FWM (EM 8.00A ) 5FWP (EM 7.20A ) 5UC4 (X-ray 2.05A ) 5UCH (X-ray 2.65A ) 5UCI (X-ray 2.70A ) 5UCJ (X-ray 1.69A ) 6N8W (X-ray 3.09A ) 6N8Y (X-ray 1.55A ) |
| DBSNP | rs11538975 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16580629, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:24880080, ECO:0000269|PubMed:9482106}. Melanosome {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:18239673}. Secreted {ECO:0000269|PubMed:20599762}. Cell membrane {ECO:0000269|PubMed:20599762}. Dynein axonemal particle {ECO:0000250|UniProtKB:Q6AZV1}. Cell surface {ECO:0000269|PubMed:21949862}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:18239673, ECO:0000269|PubMed:20599762}. |
| Mouse PG classification | NA |
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