| Gene Information | |
|---|---|
| Gene Name | ABCA8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1621 |
| Protein Names | ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000141338 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O94911 |
| Gene Card | ABCA8 |
| Uniprot ID | O94911 |
| Pfam | PF00005 |
| In ASD | no |
| Allosteric Prediction | no (-1.144918878) |
| Ortholog in Animals | Alpaca_ ABCA8 ( ortholog_one2one ) Dog_ ABCA8 ( ortholog_one2one ) Macaque_ ABCA8 ( ortholog_one2one ) Mouse_ Abca8b ( ortholog_one2one ) Pig_ ABCA8 ( ortholog_one2one ) Rat_ Abca8 ( ortholog_one2one ) Rabbit_ ABCA8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ABCA5, ABCA9, ABCA12, ABCA7, ABCA13, ABCA3, ABCA1, ABCA2, ABCA6, ABCA10, ABCA4 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with higher expression in heart, skeletal muscle and liver (PubMed:12379217, PubMed:28882873, PubMed:29300488). Highly expressed in the superior frontal white matter and inferior temporal white matter (PubMed:12379217). {ECO:0000269|PubMed:12379217, ECO:0000269|PubMed:28882873, ECO:0000269|PubMed:29300488}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16973446 rs4147979 rs35621847 rs12150510 rs144777539 rs35844316 rs16973424 rs35403175 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:28882873, ECO:0000269|PubMed:29300488}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K440}. Note=Predominantly expressed on the sinusoidal plasma membrane. {ECO:0000250|UniProtKB:Q8K440}. |
| Mouse PG classification | NA |
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