| Gene Information | |
|---|---|
| Gene Name | HSP75 |
| Organism | Homo sapiens (Human) |
| Gene Length | 704 |
| Protein Names | Heat shock protein 75 kDa, mitochondrial (HSP 75) (TNFR-associated protein 1) (Tumor necrosis factor type 1 receptor-associated protein) (TRAP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q12931 |
| Gene Card | TRAP1 |
| Uniprot ID | Q12931 |
| Pfam | PF00183 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. {ECO:0000269|PubMed:23564345}. |
| Pharmacological Animal Models | 0.014521(Chimpanzee);0.015233(Mouse);0.001341(Rat);0.021818(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4Z1F (X-ray 2.70A ) 4Z1G (X-ray 3.10A ) 4Z1H (X-ray 2.90A ) 4Z1I (X-ray 3.30A ) 5F3K (X-ray 1.82A ) 5F5R (X-ray 1.85A ) 5HPH (X-ray 2.43A ) 5Y3N (X-ray 2.40A ) 5Y3O (X-ray 2.70A ) 6XG6 (EM 3.20A ) 7C04 (X-ray 1.70A ) 7C05 (X-ray 2.59A ) 7C7B (X-ray 1.50A ) 7C7C (X-ray 3.00A ) 7KCK (EM 3.26A ) 7KCL (EM 3.14A ) 7KCM (EM 3.43A ) 7KLU (EM 3.50A ) 7KLV (EM 3.10A ) |
| DBSNP | rs13926 rs1136948 rs55766649 rs2791 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}. |
| Mouse PG classification | NA |
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