Gene Information
Gene NameFZD4
OrganismHomo sapiens (Human)
Gene Length537
Protein NamesFrizzled-4 (Fz-4) (hFz4) (FzE4) (CD antigen CD344)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000174804 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9ULV1
Gene CardFZD4
Uniprot IDQ9ULV1
PfamPF01534; PF01392
In ASDyes
Allosteric Predictionyes (0.999694293)
Ortholog in AnimalsAlpaca_ FZD4 ( ortholog_one2one )
Dog_ FZD4 ( ortholog_one2one )
GuineaPig_ FZD4 ( ortholog_one2one )
Macaque_ FZD4 ( ortholog_one2one )
Mouse_ Fzd4 ( ortholog_one2one )
Pig_ FZD4 ( ortholog_one2one )
Rat_ Fzd4 ( ortholog_one2one )
Rabbit_ FZD4 ( ortholog_one2one )
OhnologsFZD10, FZD8, FZD9
ParalogsSFRP5, SFRP1, FZD5, FZD2, FZD10, FZD9, SFRP4, FZD7, FRZB, FZD6, FZD8, SMO, FZD1, SFRP2, FZD3
TissueNA
Tissue SpecificityAlmost ubiquitous (PubMed:10544037). Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney (PubMed:10544037). Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver (PubMed:10544037). {ECO:0000269|PubMed:10544037}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5BPB  (X-ray  2.20A  )  5BPQ  (X-ray  2.40A  )  5BQC  (X-ray  3.00A  )  5BQE  (X-ray  2.30A  )  5CL1  (X-ray  3.80A  )  5CM4  (X-ray  2.40A  )  5UWG  (X-ray  2.56A  )  6BD4  (X-ray  2.40A  )  6NE1  (X-ray  3.01A  ) 
DBSNP rs61735304  rs80358281  rs139401671  rs80358282  rs80358285  rs80358284  rs80358286  rs61735303  rs80358287  rs1476724511  rs80358288  rs1064794064  rs104894223  rs80358292  rs80358293  rs80358294  rs80358297  rs80358298  rs80358300 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:30135577};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationHPG
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