| Gene Information | |
|---|---|
| Gene Name | PDHB |
| Organism | Homo sapiens (Human) |
| Gene Length | 359 |
| Protein Names | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) |
| Target Name | pyruvate dehydrogenase e1 component subunit beta, mitochondrial |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000168291 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P11177 |
| Gene Card | PDHB |
| Uniprot ID | P11177 |
| Pfam | PF02779; PF02780 |
| In ASD | no |
| Allosteric Prediction | yes (0.308753533) |
| Ortholog in Animals | Alpaca_ PDHB ( ortholog_one2one ) Dog_ PDHB ( ortholog_one2many ) GuineaPig_ PDHB ( ortholog_one2one ) Macaque_ PDHB ( ortholog_one2one ) Mouse_ Pdhb ( ortholog_one2one ) Pig_ PDHB ( ortholog_one2one ) Rat_ Pdhb ( ortholog_one2one ) Rabbit_ PDHB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | BCKDHB, TKTL2, TKTL1, TKT |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.105738(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1NI4 (X-ray 1.95A ) 2OZL (X-ray 1.90A ) 3EXE (X-ray 1.98A ) 3EXF (X-ray 3.00A ) 3EXG (X-ray 3.01A ) 3EXH (X-ray 2.44A ) 3EXI (X-ray 2.20A ) 6CER (X-ray 2.69A ) 6CFO (X-ray 2.70A ) |
| DBSNP | rs28935769 rs28933391 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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