Gene Information

Gene Information
Gene Name	HSF1
Organism	Homo sapiens (Human)
Gene Length	529
Protein Names	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1)
Target Name	heat shock factor protein 1
Target Type	NA
Gene Age	645 ( ENSG00000185122 ) 3 ( ENSG00000284774 )
Evolutionary Stage	Eukaryota
AlphaFoldDB	Q00613
Gene Card	HSF1
Uniprot ID	Q00613
Pfam	PF00447; PF06546
In ASD	no
Allosteric Prediction	yes (0.486965026)
Ortholog in Animals	Alpaca_ HSF1 ( ortholog_one2one ) Dog_ HSF1 ( ortholog_one2one ) GuineaPig_ HSF1 ( ortholog_one2one ) Macaque_ HSF1 ( ortholog_one2one ) Mouse_ Hsf1 ( ortholog_one2one ) Pig_ HSF1 ( ortholog_one2one ) Rat_ Hsf1 ( ortholog_one2one ) Rabbit_ HSF1 ( ortholog_one2one )
Ohnologs	HSF4, HSF2
Paralogs	HSF4, HSFX2, HSFX1, HSF5, HSFY2, HSFY1, HSF2, HSFX4, HSFX3
Tissue	NA
Tissue Specificity	NA
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);NULL(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	2LDU (NMR - ) 5D5U (X-ray 2.91A ) 5D5V (X-ray 2.55A ) 5HDG (X-ray 1.70A ) 5HDN (X-ray 1.68A ) 7DCJ (X-ray 2.00A ) 7DCS (X-ray 2.40A ) 7DCT (X-ray 2.36A )
DBSNP	NA
Subcellular location [CC]	Nucleus {ECO:0000269\|PubMed:10413683, ECO:0000269\|PubMed:10747973, ECO:0000269\|PubMed:11447121, ECO:0000269\|PubMed:11514557, ECO:0000269\|PubMed:12665592, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:14707147, ECO:0000269\|PubMed:15661742, ECO:0000269\|PubMed:19229036, ECO:0000269\|PubMed:21085490, ECO:0000269\|PubMed:25963659, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:27189267, ECO:0000269\|PubMed:27354066, ECO:0000269\|PubMed:7623826, ECO:0000269\|PubMed:8455624}. Cytoplasm {ECO:0000269\|PubMed:10413683, ECO:0000269\|PubMed:10747973, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:15661742, ECO:0000269\|PubMed:21085490, ECO:0000269\|PubMed:26159920, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:27354066, ECO:0000269\|PubMed:7623826, ECO:0000269\|PubMed:8455624}. Nucleus, nucleoplasm {ECO:0000269\|PubMed:10359787}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:21085490}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269\|PubMed:18794143}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269\|PubMed:18794143}. Chromosome, centromere, kinetochore {ECO:0000269\|PubMed:18794143}. Note=The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:11514557, PubMed:10359787, PubMed:25963659, PubMed:10747973, PubMed:24581496, PubMed:19229036). Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock (PubMed:11447121, PubMed:12665592, PubMed:11514557, PubMed:14707147, PubMed:10359787). Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock (PubMed:21085490). Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response (PubMed:26159920). Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) (PubMed:26359349). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes (PubMed:18794143). Colocalizes with gamma tubulin at centrosome (PubMed:18794143). Localizes at spindle pole in metaphase (PubMed:18794143). Colocalizes with PLK1 at spindle poles during prometaphase (PubMed:18794143). {ECO:0000269\|PubMed:10359787, ECO:0000269\|PubMed:10413683, ECO:0000269\|PubMed:10747973, ECO:0000269\|PubMed:11447121, ECO:0000269\|PubMed:11514557, ECO:0000269\|PubMed:12665592, ECO:0000269\|PubMed:12917326, ECO:0000269\|PubMed:14707147, ECO:0000269\|PubMed:18794143, ECO:0000269\|PubMed:21085490, ECO:0000269\|PubMed:24581496, ECO:0000269\|PubMed:25963659, ECO:0000269\|PubMed:26159920, ECO:0000269\|PubMed:26359349, ECO:0000269\|PubMed:27354066, ECO:0000269\|PubMed:8455624}.
Mouse PG classification	NA
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