| Gene Information | |
|---|---|
| Gene Name | REN |
| Organism | Homo sapiens (Human) |
| Gene Length | 232 |
| Protein Names | BTB/POZ domain-containing protein KCTD11 (KCASH1 protein) (Potassium channel tetramerization domain-containing protein 11) (RING-type E3 ubiquitin transferase subunit KCTD11) |
| Target Name | angiotensinogenase renin |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000143839 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q693B1 |
| Gene Card | KCTD11 |
| Uniprot ID | Q693B1 |
| Pfam | PF02214; PF19329 |
| In ASD | no |
| Allosteric Prediction | yes (0.750525509) |
| Ortholog in Animals | Alpaca_ REN ( ortholog_one2one ) Dog_ REN ( ortholog_one2one ) GuineaPig_ REN ( ortholog_one2one ) Macaque_ REN ( ortholog_one2one ) Mouse_ Ren1 ( ortholog_one2one ) Pig_ REN ( ortholog_one2one ) Rat_ Ren ( ortholog_one2one ) Rabbit_ REN ( ortholog_one2one ) |
| Ohnologs | PGC, CTSD |
| Paralogs | PGC, BACE2, CTSE, BACE1, NAPSA, CTSD, PGA5, PGA4, PGA3 |
| Tissue | kidney, placenta, endometrium, ovary, cortex.of.kidney |
| Tissue Specificity | Higher expression in cerebellum than in whole brain and lower expression in medulloblastoma. {ECO:0000269|PubMed:15249678}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs8080182 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
| click here to return to the previous page | |