Gene Information
Gene NameZNF683
OrganismHomo sapiens (Human)
Gene Length524
Protein NamesTissue-resident T-cell transcription regulator protein ZNF683 (Homolog of Blimp-1 in T-cell) (Hobit) (Zinc finger protein 683)
Target NameNA
Target TypeNA
Gene Age382 ( ENSG00000176083 )
Evolutionary StageEumetazoa
AlphaFoldDBQ8IZ20
Gene CardZNF683
Uniprot IDQ8IZ20
PfamPF00096
In ASDno
Allosteric Predictionno (-1.440274243)
Ortholog in AnimalsAlpaca_ ZNF683 ( ortholog_one2one )
GuineaPig_ ZNF683 ( ortholog_one2one )
Pig_ ZNF683 ( ortholog_one2one )
Rabbit_ ZNF683 ( ortholog_one2one )
OhnologsNA
ParalogsFEZF1, PRDM12, ZNF280A, ZBTB33, ZBTB21, ZNF280C, NACC2, ZNF580, ZBTB26, NACC1, ZBTB7B, GFI1, PRDM13, ZNF280B, ZBTB6, ZBTB14, GFI1B, BCL6, ZBTB49, BCL6B, ZBTB3, ZNF581, FEZF2, ZNF280D, ZBTB46, ZNF524, ZBTB12, ZBTB25
Tissuetestis
Tissue SpecificityExpressed in terminally differentiated effector CD8(+) T-cells, but not in naive and central memory cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level) (PubMed:26179882). Expressed strongly in effector-type CD8(+) T-cells and weakly in naive and memory CD8(+) T-cells (PubMed:26179882). Expressed in terminally differentiated natural killer (NK) cells (PubMed:26179882). Isoform 2 is strongly expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882). Isoform 1 is expressed in effector CD8(+) T and natural killer (NK) cells (PubMed:26179882). {ECO:0000269|PubMed:26179882}.;
(Microbial infection) Expressed in cytomegalovirus (CMV)-infected effector CD8(+) T-cells (at protein level) (PubMed:20921622). {ECO:0000269|PubMed:20921622}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35040247  rs10794532  rs10794531  rs17852672  rs11247933 
Subcellular location [CC]Nucleus {ECO:0000305}.
Mouse PG classificationNA
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