Gene Information
Gene NameHSD17B6
OrganismHomo sapiens (Human)
Gene Length317
Protein Names17-beta-hydroxysteroid dehydrogenase type 6 (17-beta-HSD 6) (17-beta-HSD6) (EC 1.1.1.105) (EC 1.1.1.209) (EC 1.1.1.239) (EC 1.1.1.53) (EC 1.1.1.62) (3-alpha->beta-hydroxysteroid epimerase) (3-alpha->beta-HSE) (Oxidative 3-alpha hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 6)
Target NameNA
Target TypeNA
Gene Age168 ( ENSG00000025423 )
Evolutionary StageEuk+Bac
AlphaFoldDBO14756
Gene CardHSD17B6
Uniprot IDO14756
PfamPF00106
In ASDno
Allosteric Predictionno (-0.064994059)
Ortholog in AnimalsAlpaca_ HSD17B6 ( ortholog_one2one )
Dog_ HSD17B6 ( ortholog_one2one )
Macaque_ HSD17B6 ( ortholog_one2one )
Mouse_ Hsd17b6 ( ortholog_one2one )
Pig_ HSD17B6 ( ortholog_one2one )
Rat_ Hsd17b6 ( ortholog_one2many )
OhnologsDHRS9, BDH1
ParalogsSDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3
TissueNA
Tissue SpecificityDetected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:9188497}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Microsome membrane {ECO:0000269|PubMed:11360992};
Peripheral membrane protein {ECO:0000269|PubMed:11360992};
Lumenal side {ECO:0000269|PubMed:11360992}. Early endosome membrane {ECO:0000305};
Peripheral membrane protein {ECO:0000305};
Lumenal side {ECO:0000305}.
Mouse PG classificationNA
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