| Gene Information | |
|---|---|
| Gene Name | HSD17B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | 17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239) |
| Target Name | estradiol 17-beta-dehydrogenase 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000086696 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P37059 |
| Gene Card | HSD17B2 |
| Uniprot ID | P37059 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | yes (0.23948617) |
| Ortholog in Animals | Alpaca_ HSD17B2 ( ortholog_one2one ) Dog_ HSD17B2 ( ortholog_one2one ) GuineaPig_ HSD17B2 ( ortholog_one2one ) Macaque_ HSD17B2 ( ortholog_one2one ) Mouse_ Hsd17b2 ( ortholog_one2one ) Pig_ HSD17B2 ( ortholog_one2one ) Rat_ Hsd17b2 ( ortholog_one2one ) Rabbit_ HSD17B2 ( ortholog_one2one ) |
| Ohnologs | HSD11B2 |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | duodenum, placenta, liver, small.intestine |
| Tissue Specificity | Expressed in placenta. {ECO:0000269|PubMed:8099587}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs8191136 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10385431}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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