| Gene Information | |
|---|---|
| Gene Name | HSD17B12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (17-beta-hydroxysteroid dehydrogenase 12) (17-beta-HSD 12) (3-ketoacyl-CoA reductase) (KAR) (Estradiol 17-beta-dehydrogenase 12) (EC 1.1.1.62) (Short chain dehydrogenase/reductase family 12C member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000149084 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q53GQ0 |
| Gene Card | HSD17B12 |
| Uniprot ID | Q53GQ0 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.376835635) |
| Ortholog in Animals | Alpaca_ HSD17B12 ( ortholog_one2one ) Dog_ HSD17B12 ( ortholog_one2one ) GuineaPig_ HSD17B12 ( ortholog_one2one ) Macaque_ HSD17B12 ( ortholog_one2one ) Mouse_ Hsd17b12 ( ortholog_one2one ) Pig_ HSD17B12 ( ortholog_one2one ) Rat_ Hsd17b12 ( ortholog_one2one ) Rabbit_ HSD17B12 ( ortholog_one2one ) |
| Ohnologs | HSDL1 |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | NA |
| Tissue Specificity | Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets. {ECO:0000269|PubMed:12482854, ECO:0000269|PubMed:16113833, ECO:0000269|PubMed:16166196}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11555762 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12482854}; Multi-pass membrane protein {ECO:0000269|PubMed:12482854}. |
| Mouse PG classification | NA |
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