| Gene Information | |
|---|---|
| Gene Name | HSD11B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 405 |
| Protein Names | 11-beta-hydroxysteroid dehydrogenase type 2 (11-DH2) (11-beta-HSD2) (EC 1.1.1.-) (11-beta-hydroxysteroid dehydrogenase type II) (11-HSD type II) (11-beta-HSD type II) (Corticosteroid 11-beta-dehydrogenase isozyme 2) (NAD-dependent 11-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 3) |
| Target Name | corticosteroid 11-beta-dehydrogenase 2 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000176387 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P80365 |
| Gene Card | HSD11B2 |
| Uniprot ID | P80365 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | yes (1.067885616) |
| Ortholog in Animals | Alpaca_ HSD11B2 ( ortholog_one2one ) Dog_ HSD11B2 ( ortholog_one2one ) GuineaPig_ HSD11B2 ( ortholog_one2one ) Macaque_ HSD11B2 ( ortholog_one2one ) Mouse_ Hsd11b2 ( ortholog_one2one ) Pig_ HSD11B2 ( ortholog_one2one ) Rat_ Hsd11b2 ( ortholog_one2one ) Rabbit_ HSD11B2 ( ortholog_one2one ) |
| Ohnologs | HSD17B2 |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, DHRS3, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | NA |
| Tissue Specificity | Expressed in kidney, placenta, pancreas, prostate, ovary, small intestine and colon, and in lower levels in the spleen and testis (PubMed:7859916). At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071). {ECO:0000269|PubMed:7859916, ECO:0000269|PubMed:8530071}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs13306425 rs768507002 rs121917780 rs28934592 rs28934591 rs121917833 rs121917782 rs1309642469 rs28934594 rs1453036708 rs121917781 rs387907117 |
| Subcellular location [CC] | Microsome {ECO:0000269|PubMed:17314322}. Endoplasmic reticulum {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:17314322}. |
| Mouse PG classification | NA |
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