| Gene Information | |
|---|---|
| Gene Name | HSCB |
| Organism | Homo sapiens (Human) |
| Gene Length | 235 |
| Protein Names | Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000100209 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8IWL3 |
| Gene Card | HSCB |
| Uniprot ID | Q8IWL3 |
| Pfam | PF18256; PF07743 |
| In ASD | no |
| Allosteric Prediction | no (-0.589603432) |
| Ortholog in Animals | Alpaca_ HSCB ( ortholog_one2one ) Dog_ HSCB ( ortholog_one2one ) GuineaPig_ HSCB ( ortholog_one2one ) Macaque_ HSCB ( ortholog_one2one ) Mouse_ Hscb ( ortholog_one2one ) Pig_ HSCB ( ortholog_one2one ) Rat_ Hscb ( ortholog_one2one ) Rabbit_ HSCB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart. {ECO:0000269|PubMed:12938016, ECO:0000269|PubMed:20668094}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.010526(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3BVO (X-ray 3.00A ) |
| DBSNP | rs17886090 rs17884212 |
| Subcellular location [CC] | [Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:20668094, ECO:0000269|PubMed:29309586}.; [Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]: Mitochondrion {ECO:0000269|PubMed:20668094}. |
| Mouse PG classification | NA |
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