| Gene Information | |
|---|---|
| Gene Name | BARD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 777 |
| Protein Names | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000138376 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99728 |
| Gene Card | BARD1 |
| Uniprot ID | Q99728 |
| Pfam | PF12796; PF14835 |
| In ASD | no |
| Allosteric Prediction | yes (0.139533931) |
| Ortholog in Animals | Alpaca_ BARD1 ( ortholog_one2one ) GuineaPig_ BARD1 ( ortholog_one2one ) Macaque_ BARD1 ( ortholog_one2one ) Mouse_ Bard1 ( ortholog_one2one ) Pig_ BARD1 ( ortholog_one2one ) Rat_ Bard1 ( ortholog_one2one ) Rabbit_ BARD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JM7 (NMR - ) 2NTE (X-ray 1.90A ) 2R1Z (X-ray 2.10A ) 3C5R (X-ray 2.00A ) 3FA2 (X-ray 2.20A ) 6M14 (X-ray 1.88A ) 7E8I (EM 3.10A ) 7JZV (EM 3.90A ) 7LYB (EM 3.28A ) 7LYC (EM 2.94A ) |
| DBSNP | rs1048108 rs753377280 rs16852741 rs3738885 rs2229571 rs2070094 rs28997576 rs2228456 rs3738888 rs111367604 rs13389423 rs142155101 |
| Subcellular location [CC] | Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex. |
| Mouse PG classification | LPG |
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