| Gene Information | |
|---|---|
| Gene Name | HORMAD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 394 |
| Protein Names | HORMA domain-containing protein 1 (Cancer/testis antigen 46) (CT46) (Newborn ovary HORMA protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000143452 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86X24 |
| Gene Card | HORMAD1 |
| Uniprot ID | Q86X24 |
| Pfam | PF02301 |
| In ASD | no |
| Allosteric Prediction | no (-1.315451494) |
| Ortholog in Animals | Alpaca_ HORMAD1 ( ortholog_one2one ) Dog_ HORMAD1 ( ortholog_one2one ) GuineaPig_ HORMAD1 ( ortholog_one2one ) Macaque_ HORMAD1 ( ortholog_one2one ) Mouse_ Hormad1 ( ortholog_one2one ) Pig_ HORMAD1 ( ortholog_one2one ) Rat_ Hormad1 ( ortholog_one2one ) Rabbit_ HORMAD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HORMAD2 |
| Tissue | testis |
| Tissue Specificity | Testis-specific. Over-expressed in carcinomas. {ECO:0000269|PubMed:15999985}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004740(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1336900 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}. |
| Mouse PG classification | NA |
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