Gene Information
Gene NameRIPK1
OrganismHomo sapiens (Human)
Gene Length671
Protein NamesReceptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Target Namereceptor-interacting protein 1
Target TypeClinical trial target
Gene Age544 ( ENSG00000137275 )
Evolutionary StageEukaryota
AlphaFoldDBQ13546
Gene CardRIPK1
Uniprot IDQ13546
PfamPF00531; PF07714; PF12721
In ASDyes
Allosteric Predictionyes (1.000054995)
Ortholog in AnimalsAlpaca_ RIPK1 ( ortholog_one2one )
Dog_ RIPK1 ( ortholog_one2one )
GuineaPig_ RIPK1 ( ortholog_one2one )
Macaque_ RIPK1 ( ortholog_one2one )
Mouse_ Ripk1 ( ortholog_one2one )
Pig_ RIPK1 ( ortholog_one2one )
Rat_ Ripk1 ( ortholog_one2one )
Rabbit_ RIPK1 ( ortholog_one2one )
OhnologsNA
ParalogsLIMK2, LRRK2, TNNI3K, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.265492(Rat);0.074291(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4ITH  (X-ray  2.25A  )  4ITI  (X-ray  2.86A  )  4ITJ  (X-ray  1.80A  )  4NEU  (X-ray  2.57A  )  5HX6  (X-ray  2.23A  )  5TX5  (X-ray  2.56A  )  5V7Z  (NMR  -  )  6AC5  (X-ray  1.45A  )  6C3E  (X-ray  2.60A  )  6C4D  (X-ray  2.52A  )  6HHO  (X-ray  3.49A  )  6NW2  (X-ray  2.00A  )  6NYH  (X-ray  2.10A  )  6OCQ  (X-ray  2.79A  )  6R5F  (X-ray  3.25A  )  6RLN  (X-ray  2.87A  )  7CJB  (X-ray  2.80A  )  7FCZ  (X-ray  2.21A  )  7FD0  (X-ray  2.00A  ) 
DBSNP rs774996232  rs758268804  rs759012409  rs17548383  rs1760720617  rs34872409  rs3173519  rs35722193  rs55861377 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:Q60855}. Cell membrane {ECO:0000250|UniProtKB:Q9ZUF4}.
Mouse PG classificationNA
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