| Gene Information | |
|---|---|
| Gene Name | TPT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 172 |
| Protein Names | Translationally-controlled tumor protein (TCTP) (Fortilin) (Histamine-releasing factor) (HRF) (p23) |
| Target Name | translationally-controlled tumor protein |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000133112 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P13693 |
| Gene Card | TPT1 |
| Uniprot ID | P13693 |
| Pfam | PF00838 |
| In ASD | no |
| Allosteric Prediction | yes (0.076615072) |
| Ortholog in Animals | Alpaca_ TPT1 ( ortholog_one2many ) Dog_ TPT1 ( ortholog_one2one ) Macaque_ TPT1 ( ortholog_one2one ) Mouse_ Tpt1 ( ortholog_one2one ) Pig_ TPT1 ( ortholog_one2one ) Rat_ RGD1563739 ( ortholog_one2many ) Rat_ Tpt1 ( ortholog_one2many ) Rat_ AABR07058831.1 ( ortholog_one2many ) Rat_ RGD1565260 ( ortholog_one2many ) Rat_ AABR07024742.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Found in several healthy and tumoral cells including erythrocytes, hepatocytes, macrophages, platelets, keratinocytes, erythroleukemia cells, gliomas, melanomas, hepatoblastomas, and lymphomas. It cannot be detected in kidney and renal cell carcinoma (RCC). Expressed in placenta and prostate. {ECO:0000269|PubMed:9059837}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YZ1 (X-ray 2.00A ) 2HR9 (NMR - ) 3EBM (X-ray 2.60A ) 4Z9V (X-ray 2.10A ) 5O9L (X-ray 1.75A ) 5O9M (X-ray 1.40A ) 6IZB (X-ray 1.90A ) 6IZE (X-ray 2.29A ) |
| DBSNP | rs3087989 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9059837}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |