| Gene Information | |
|---|---|
| Gene Name | TSC22D3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 134 |
| Protein Names | TSC22 domain family protein 3 (DSIP-immunoreactive peptide) (Protein DIP) (hDIP) (Delta sleep-inducing peptide immunoreactor) (Glucocorticoid-induced leucine zipper protein) (GILZ) (TSC-22-like protein) (TSC-22-related protein) (TSC-22R) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000157514 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99576 |
| Gene Card | TSC22D3 |
| Uniprot ID | Q99576 |
| Pfam | PF01166 |
| In ASD | no |
| Allosteric Prediction | no (-0.088855843) |
| Ortholog in Animals | Alpaca_ TSC22D3 ( ortholog_one2one ) Dog_ TSC22D3 ( ortholog_one2one ) GuineaPig_ TSC22D3 ( ortholog_one2one ) Macaque_ TSC22D3 ( ortholog_one2one ) Mouse_ Tsc22d3 ( ortholog_one2one ) Pig_ TSC22D3 ( ortholog_one2one ) Rat_ Tsc22d3 ( ortholog_one2one ) Rabbit_ TSC22D3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TSC22D2, TSC22D1, TSC22D4 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells. {ECO:0000269|PubMed:11313722, ECO:0000269|PubMed:12393603}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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