| Gene Information | |
|---|---|
| Gene Name | HRIHFB2122 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2365 |
| Protein Names | TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H2D6 |
| Gene Card | TRIOBP |
| Uniprot ID | Q9H2D6 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. {ECO:0000269|PubMed:16385458}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12628603 rs4821700 rs41302575 rs9610841 rs549095193 rs5756795 rs739138 rs8140207 rs8140958 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9853615}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9853615}. Note=Localized to F-actin in a periodic pattern. {ECO:0000269|PubMed:9853615}.; [Isoform 1]: Nucleus {ECO:0000269|PubMed:22820163}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22820163}. Midbody {ECO:0000269|PubMed:22820163}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. {ECO:0000269|PubMed:22820163}. |
| Mouse PG classification | NA |
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