| Gene Information | |
|---|---|
| Gene Name | HRH4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Histamine H4 receptor (H4R) (HH4R) (AXOR35) (G-protein coupled receptor 105) (GPRv53) (Pfi-013) (SP9144) |
| Target Name | histamine h4 receptor |
| Target Type | Clinical trial target |
| Gene Age | 382 ( ENSG00000134489 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H3N8 |
| Gene Card | HRH4 |
| Uniprot ID | Q9H3N8 |
| Pfam | PF00001 |
| In ASD | no |
| Allosteric Prediction | yes (1.216237877) |
| Ortholog in Animals | Alpaca_ HRH4 ( ortholog_one2one ) Dog_ HRH4 ( ortholog_one2one ) GuineaPig_ HRH4 ( ortholog_one2one ) Macaque_ HRH4 ( ortholog_one2one ) Mouse_ Hrh4 ( ortholog_one2one ) Pig_ HRH4 ( ortholog_one2one ) Rat_ Hrh4 ( ortholog_one2one ) Rabbit_ HRH4 ( ortholog_one2one ) |
| Ohnologs | HRH3 |
| Paralogs | HRH2, TAAR6, DRD4, HRH1, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269|PubMed:12503632}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11665084 rs11662595 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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