| Gene Information | |
|---|---|
| Gene Name | HRH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Histamine H1 receptor (H1R) (HH1R) |
| Target Name | histamine h1 receptor |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000196639 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35367 |
| Gene Card | HRH1 |
| Uniprot ID | P35367 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.517453223) |
| Ortholog in Animals | Alpaca_ HRH1 ( ortholog_one2one ) Dog_ HRH1 ( ortholog_one2one ) GuineaPig_ HRH1 ( ortholog_one2one ) Macaque_ HRH1 ( ortholog_one2one ) Mouse_ Hrh1 ( ortholog_one2one ) Pig_ HRH1 ( ortholog_one2one ) Rat_ Hrh1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HRH2, TAAR6, DRD4, DRD1, GPR52, HTR1A, HTR1D, CHRM3, CHRM4, HRH3, TAAR5, HTR4, TAAR1, GPR21, CHRM1, HRH4, TAAR9, CHRM5, TAAR8, DRD3, GPR84, CHRM2, GPR161, DRD5, TAAR2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RZE (X-ray 3.10A ) 7DFL (EM 3.30A ) |
| DBSNP | rs2067466 rs7651620 rs1370695377 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21697825}; Multi-pass membrane protein {ECO:0000269|PubMed:21697825}. |
| Mouse PG classification | NA |
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