| Gene Information | |
|---|---|
| Gene Name | HACD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 288 |
| Protein Names | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 1) (HACD1) (Cementum-attachment protein) (CAP) (Protein-tyrosine phosphatase-like member A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000165996 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | B0YJ81 |
| Gene Card | HACD1 |
| Uniprot ID | B0YJ81 |
| Pfam | PF04387 |
| In ASD | no |
| Allosteric Prediction | no (-0.235580778) |
| Ortholog in Animals | Alpaca_ HACD1 ( ortholog_one2one ) Dog_ HACD1 ( ortholog_one2one ) GuineaPig_ HACD1 ( ortholog_one2one ) Macaque_ HACD1 ( ortholog_one2one ) Mouse_ Hacd1 ( ortholog_one2one ) Pig_ HACD1 ( ortholog_one2one ) Rat_ Hacd1 ( ortholog_one2one ) Rabbit_ HACD1 ( ortholog_one2one ) |
| Ohnologs | HACD2 |
| Paralogs | HACD2, HACD4, HACD3 |
| Tissue | heart, smooth.muscle |
| Tissue Specificity | Isoform 1 is highly expressed in the myocardium, and to a lesser extent in skeletal and smooth muscular tissues including those from stomach, jejunum, and bladder. Also detected in gingival fibroblasts, periodontal ligament cells, osteoblasts and cementoblasts (PubMed:11054553, PubMed:22067203). Isoform 2 is specifically expressed by cementoblasts but also detected in periodontal ligament cells, heart, liver and kidney (at protein level) (PubMed:22067203). {ECO:0000269|PubMed:11054553, ECO:0000269|PubMed:22067203}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs7895850 rs7895850 rs11254692 rs1053926 |
| Subcellular location [CC] | [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}. |
| Mouse PG classification | NA |
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