| Gene Information | |
|---|---|
| Gene Name | HR |
| Organism | Homo sapiens (Human) |
| Gene Length | 1189 |
| Protein Names | Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000168453 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O43593 |
| Gene Card | HR |
| Uniprot ID | O43593 |
| Pfam | PF02373 |
| In ASD | no |
| Allosteric Prediction | no (-0.990752979) |
| Ortholog in Animals | Alpaca_ HR ( ortholog_one2one ) Dog_ HR ( ortholog_one2one ) GuineaPig_ HR ( ortholog_one2one ) Macaque_ HR ( ortholog_one2one ) Mouse_ Hr ( ortholog_one2one ) Pig_ HR ( ortholog_one2one ) Rat_ Hr ( ortholog_one2one ) Rabbit_ HR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | JMJD1C, KDM3A, KDM3B |
| Tissue | skin |
| Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. {ECO:0000269|PubMed:10051399, ECO:0000269|PubMed:9736769}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12675375 rs56140348 rs117197822 rs11990421 rs121434451 rs7014851 rs121434448 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | HPG |
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