| Gene Information | |
|---|---|
| Gene Name | DTX3L |
| Organism | Homo sapiens (Human) |
| Gene Length | 740 |
| Protein Names | E3 ubiquitin-protein ligase DTX3L (EC 2.3.2.27) (B-lymphoma- and BAL-associated protein) (Protein deltex-3-like) (RING-type E3 ubiquitin transferase DTX3L) (Rhysin-2) (Rhysin2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000163840 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TDB6 |
| Gene Card | DTX3L |
| Uniprot ID | Q8TDB6 |
| Pfam | PF18102 |
| In ASD | no |
| Allosteric Prediction | no (-0.502370488) |
| Ortholog in Animals | Alpaca_ DTX3L ( ortholog_one2one ) Dog_ DTX3L ( ortholog_one2one ) GuineaPig_ DTX3L ( ortholog_one2one ) Macaque_ DTX3L ( ortholog_one2one ) Mouse_ Dtx3l ( ortholog_one2one ) Pig_ DTX3L ( ortholog_one2one ) Rat_ Dtx3l ( ortholog_one2one ) Rabbit_ DTX3L ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DTX1, DTX4, DTX3, DTX2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3PG6 (X-ray 1.70A ) |
| DBSNP | rs2332285 rs9868175 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788}. Nucleus {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:26479788}. Early endosome membrane {ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:24790097}. Lysosome membrane {ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:24790097}. Note=Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272). Localization to early endosomes is increased upon CXCL12 stimulation where it co-localizes with ITCH, CXCL4, HGS and STAM (PubMed:24790097). A minor proportion localizes to lysosomes (PubMed:24790097). {ECO:0000269|PubMed:23230272, ECO:0000269|PubMed:24790097, ECO:0000269|PubMed:26479788}. |
| Mouse PG classification | NA |
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