| Gene Information | |
|---|---|
| Gene Name | OTUB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 271 |
| Protein Names | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000167770 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96FW1 |
| Gene Card | OTUB1 |
| Uniprot ID | Q96FW1 |
| Pfam | PF10275 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999904002) |
| Ortholog in Animals | Alpaca_ OTUB1 ( ortholog_one2one ) Dog_ OTUB1 ( ortholog_one2one ) GuineaPig_ OTUB1 ( ortholog_one2one ) Mouse_ Otub1 ( ortholog_one2one ) Pig_ OTUB1 ( ortholog_one2one ) Rat_ AABR07056013.1 ( ortholog_one2many ) Rat_ Otub1 ( ortholog_one2many ) |
| Ohnologs | OTUB2 |
| Paralogs | OTUB2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is ubiquitous. Isoform 2 is expressed only in lymphoid tissues such as tonsils, lymph nodes and spleen, as well as peripheral blood mononuclear cells. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:14661020}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2ZFY (X-ray 1.69A ) 3VON (X-ray 3.15A ) 4DDG (X-ray 3.30A ) 4DDI (X-ray 3.80A ) 4DHZ (X-ray 3.11A ) 4I6L (X-ray 2.49A ) 4LDT (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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