| Gene Information | |
|---|---|
| Gene Name | HPSE2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Inactive heparanase-2 (Hpa2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000172987 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q8WWQ2 |
| Gene Card | HPSE2 |
| Uniprot ID | Q8WWQ2 |
| Pfam | PF03662 |
| In ASD | no |
| Allosteric Prediction | no (-0.854695368) |
| Ortholog in Animals | Alpaca_ HPSE2 ( ortholog_one2one ) Dog_ HPSE2 ( ortholog_one2one ) GuineaPig_ HPSE2 ( ortholog_one2one ) Macaque_ HPSE2 ( ortholog_one2one ) Mouse_ Hpse2 ( ortholog_one2one ) Pig_ HPSE2 ( ortholog_one2one ) Rat_ Hpse2 ( ortholog_one2one ) Rabbit_ HPSE2 ( ortholog_one2one ) |
| Ohnologs | HPSE |
| Paralogs | HPSE |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues. {ECO:0000269|PubMed:11027606, ECO:0000269|PubMed:20560210}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs17110744 rs10883100 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20576607}. |
| Mouse PG classification | HPG |
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