| Gene Information | |
|---|---|
| Gene Name | HPSE |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit] |
| Target Name | heparanase |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000173083 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y251 |
| Gene Card | HPSE |
| Uniprot ID | Q9Y251 |
| Pfam | PF03662 |
| In ASD | no |
| Allosteric Prediction | yes (0.183447728) |
| Ortholog in Animals | Alpaca_ HPSE ( ortholog_one2one ) Dog_ HPSE ( ortholog_one2one ) GuineaPig_ HPSE ( ortholog_one2one ) Macaque_ HPSE ( ortholog_one2one ) Mouse_ Hpse ( ortholog_one2one ) Pig_ HPSE ( ortholog_one2one ) Rat_ Hpse ( ortholog_one2one ) Rabbit_ HPSE ( ortholog_one2one ) |
| Ohnologs | HPSE2 |
| Paralogs | HPSE2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henle's and Huxley's layers of inner the root sheath (IRS) at anagen phase. {ECO:0000269|PubMed:10395326, ECO:0000269|PubMed:10405343, ECO:0000269|PubMed:10764835, ECO:0000269|PubMed:18557927, ECO:0000269|PubMed:20309870}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5E8M (X-ray 1.75A ) 5E97 (X-ray 1.63A ) 5E98 (X-ray 1.63A ) 5E9B (X-ray 1.88A ) 5E9C (X-ray 1.73A ) 5L9Y (X-ray 1.88A ) 5L9Z (X-ray 1.57A ) 5LA4 (X-ray 1.90A ) 5LA7 (X-ray 1.94A ) 6ZDM (X-ray 1.71A ) 7PR7 (X-ray 1.52A ) 7PR8 (X-ray 1.66A ) 7PRT (X-ray 1.70A ) 7RG8 (X-ray 1.30A ) |
| DBSNP | rs11099592 |
| Subcellular location [CC] | Lysosome membrane; Peripheral membrane protein. Secreted. Nucleus. Note=Proheparanase is secreted via vesicles of the Golgi. Interacts with cell membrane heparan sulfate proteoglycans (HSPGs). Endocytosed and accumulates in endosomes. Transferred to lysosomes where it is proteolytically cleaved to produce the active enzyme. Under certain stimuli, transferred to the cell surface. Associates with lipid rafts. Colocalizes with SDC1 in endosomal/lysosomal vesicles. Accumulates in perinuclear lysosomal vesicles. Heparin retains proheparanase in the extracellular medium (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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