| Gene Information | |
|---|---|
| Gene Name | HPRT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 218 |
| Protein Names | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) |
| Target Name | hypoxanthine-guanine phosphoribosyltransferase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000165704 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P00492 |
| Gene Card | HPRT1 |
| Uniprot ID | P00492 |
| Pfam | PF00156 |
| In ASD | no |
| Allosteric Prediction | yes (0.58266541) |
| Ortholog in Animals | Alpaca_ HPRT1 ( ortholog_one2one ) Dog_ HPRT1 ( ortholog_one2many ) GuineaPig_ HPRT1 ( ortholog_one2one ) Macaque_ HPRT1 ( ortholog_one2one ) Mouse_ Hprt ( ortholog_one2one ) Pig_ HPRT1 ( ortholog_one2one ) Rat_ Hprt1 ( ortholog_one2one ) Rabbit_ HPRT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PGM1, PGM2L1, PGM2, PGM3, PRTFDC1, PGM5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BZY (X-ray 2.00A ) 1D6N (X-ray 2.70A ) 1HMP (X-ray 2.50A ) 1Z7G (X-ray 1.90A ) 2VFA (X-ray 2.80A ) 3GEP (X-ray 2.60A ) 3GGC (X-ray 2.78A ) 3GGJ (X-ray 2.60A ) 4IJQ (X-ray 2.00A ) 4KN6 (X-ray 2.73A ) 4RAB (X-ray 2.26A ) 4RAC (X-ray 2.05A ) 4RAD (X-ray 2.00A ) 4RAN (X-ray 2.55A ) 4RAO (X-ray 1.87A ) 4RAQ (X-ray 2.53A ) 5BRN (X-ray 2.30A ) 5BSK (X-ray 2.61A ) 5HIA (X-ray 1.77A ) 5W8V (X-ray 2.35A ) 6BNJ (X-ray 1.91A ) 7SAN (X-ray 2.58A ) |
| DBSNP | rs137852499 rs137852480 rs137852491 rs387906725 rs1556026984 rs137852494 rs137852502 rs137852495 rs137852500 rs1228634091 rs137852487 rs137852488 rs137852481 rs137852501 rs137852478 rs137852485 rs137852482 rs137852483 rs137852477 rs137852496 rs137852484 rs137852498 rs137852493 rs137852492 rs137852504 rs267606863 rs137852486 rs137852479 rs137852490 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | HPG |
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