| Gene Information | |
|---|---|
| Gene Name | HPR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 657 |
| Protein Names | THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96FV9 |
| Gene Card | THOC1 |
| Uniprot ID | Q96FV9 |
| Pfam | PF00531; PF11957 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. {ECO:0000269|PubMed:15358532, ECO:0000269|PubMed:15833825}. |
| Pharmacological Animal Models | 0.152275(Chimpanzee);0.154554(Mouse);0.099174(Rat);0.036242(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WXP (NMR - ) 7APK (EM 3.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.; [Isoform 2]: Cytoplasm. |
| Mouse PG classification | NA |
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