| Gene Information | |
|---|---|
| Gene Name | HPN |
| Organism | Homo sapiens (Human) |
| Gene Length | 417 |
| Protein Names | Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] |
| Target Name | serine protease hepsin |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000105707 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P05981 |
| Gene Card | HPN |
| Uniprot ID | P05981 |
| Pfam | PF09272; PF00089 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000364963) |
| Ortholog in Animals | Alpaca_ HPN ( ortholog_one2one ) Dog_ HPN ( ortholog_one2one ) GuineaPig_ HPN ( ortholog_one2one ) Macaque_ HPN ( ortholog_one2one ) Mouse_ Hpn ( ortholog_one2one ) Pig_ HPN ( ortholog_one2one ) Rat_ Hpn ( ortholog_one2one ) Rabbit_ HPN ( ortholog_one2one ) |
| Ohnologs | TMPRSS3, TMPRSS4, ST14, TMPRSS5, PRSS38 |
| Paralogs | TMPRSS15, TMPRSS6, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | kidney, liver |
| Tissue Specificity | Detected in liver and kidney. {ECO:0000269|PubMed:21875933}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1O5E (X-ray 1.75A ) 1O5F (X-ray 1.78A ) 1P57 (X-ray 1.75A ) 1Z8G (X-ray 1.55A ) 3T2N (X-ray 2.55A ) 5CE1 (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1885621}; Single-pass type II membrane protein {ECO:0000269|PubMed:1885621}. Apical cell membrane {ECO:0000269|PubMed:26673890}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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