Gene Information | |
---|---|
Gene Name | HPK1 |
Organism | Homo sapiens (Human) |
Gene Length | 833 |
Protein Names | Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) |
Target Name | NA |
Target Type | NA |
Gene Age | NA |
Evolutionary Stage | NA |
AlphaFoldDB | Q92918 |
Gene Card | MAP4K1 |
Uniprot ID | Q92918 |
Pfam | PF00780; PF00069 |
In ASD | yes |
Allosteric Prediction | NA |
Ortholog in Animals | NA |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 6CQD (X-ray 2.12A ) 6CQE (X-ray 1.89A ) 6CQF (X-ray 2.25A ) 6NFY (X-ray 2.17A ) 6NFZ (X-ray 2.97A ) 6NG0 (X-ray 2.05A ) 7KAC (X-ray 1.85A ) 7L24 (X-ray 2.68A ) 7L25 (X-ray 1.85A ) 7L26 (X-ray 2.30A ) 7M0K (X-ray 2.01A ) 7M0L (X-ray 2.43A ) 7M0M (X-ray 1.93A ) 7R9L (X-ray 2.33A ) 7R9N (X-ray 1.50A ) 7R9P (X-ray 2.27A ) 7R9T (X-ray 2.00A ) 7SIU (X-ray 1.79A ) |
DBSNP | rs55924696 rs34591617 rs56060067 rs1238066548 rs12975825 |
Subcellular location [CC] | NA |
Mouse PG classification | NA |
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