| Gene Information | |
|---|---|
| Gene Name | HPF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 346 |
| Protein Names | Histone PARylation factor 1 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000056050 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NWY4 |
| Gene Card | HPF1 |
| Uniprot ID | Q9NWY4 |
| Pfam | PF10228 |
| In ASD | no |
| Allosteric Prediction | no (-1.046465252) |
| Ortholog in Animals | Alpaca_ HPF1 ( ortholog_one2one ) Dog_ HPF1 ( ortholog_one2one ) Macaque_ HPF1 ( ortholog_one2one ) Mouse_ Hpf1 ( ortholog_one2one ) Pig_ HPF1 ( ortholog_one2one ) Rat_ Hpf1 ( ortholog_one2one ) Rabbit_ HPF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6M3G (X-ray 1.57A ) 6M3I (X-ray 1.98A ) 6TX2 (X-ray 2.09A ) 6TX3 (X-ray 2.96A ) 6X0L (EM 3.90A ) 6X0M (EM 6.30A ) 6X0N (EM 10.00A ) |
| DBSNP | rs1047642 rs1047706 |
| Subcellular location [CC] | Chromosome {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:32939087}. Nucleus {ECO:0000269|PubMed:27067600}. Note=Localizes to DNA damage sites; chromatin localization is dependent on PARP1 and PARP2. {ECO:0000269|PubMed:27067600, ECO:0000269|PubMed:32939087}. |
| Mouse PG classification | NA |
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