| Gene Information | |
|---|---|
| Gene Name | HPD |
| Organism | Homo sapiens (Human) |
| Gene Length | 393 |
| Protein Names | 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) (4-hydroxyphenylpyruvic acid oxidase) (4HPPD) (HPD) (HPPDase) |
| Target Name | hydroxyphenylpyruvate dioxygenase |
| Target Type | Successful target |
| Gene Age | 1488 ( ENSG00000158104 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P32754 |
| Gene Card | HPD |
| Uniprot ID | P32754 |
| Pfam | PF00903 |
| In ASD | no |
| Allosteric Prediction | yes (0.686230181) |
| Ortholog in Animals | Alpaca_ HPD ( ortholog_one2one ) Dog_ HPD ( ortholog_one2one ) GuineaPig_ HPD ( ortholog_one2one ) Macaque_ HPD ( ortholog_one2one ) Mouse_ Hpd ( ortholog_one2one ) Pig_ HPD ( ortholog_one2one ) Rat_ Hpd ( ortholog_one2one ) Rabbit_ HPD ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HPDL |
| Tissue | liver, kidney, medulla.oblongata |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3ISQ (X-ray 1.75A ) 5EC3 (X-ray 2.10A ) |
| DBSNP | rs1154510 rs11833399 rs137852865 rs36023382 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P32755}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. |
| Mouse PG classification | NA |
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