| Gene Information | |
|---|---|
| Gene Name | JMJD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 403 |
| Protein Names | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000070495 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6NYC1 |
| Gene Card | JMJD6 |
| Uniprot ID | Q6NYC1 |
| Pfam | PF02373 |
| In ASD | no |
| Allosteric Prediction | no (-0.389356273) |
| Ortholog in Animals | Alpaca_ JMJD6 ( ortholog_one2one ) Dog_ JMJD6 ( ortholog_one2one ) GuineaPig_ JMJD6 ( ortholog_one2one ) Macaque_ JMJD6 ( ortholog_one2one ) Mouse_ Jmjd6 ( ortholog_one2one ) Pig_ JMJD6 ( ortholog_one2one ) Rat_ Jmjd6 ( ortholog_one2one ) Rabbit_ JMJD6 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | JMJD8, JMJD4 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells. {ECO:0000269|PubMed:15072554, ECO:0000269|PubMed:15622002, ECO:0000269|PubMed:9628581}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3K2O (X-ray 1.75A ) 3LD8 (X-ray 2.70A ) 3LDB (X-ray 2.70A ) 6BNH (NMR - ) 6GDY (X-ray 2.04A ) 6MEV (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:14729065, ECO:0000269|PubMed:21060799}. Nucleus, nucleolus {ECO:0000269|PubMed:21060799}. Cytoplasm {ECO:0000269|PubMed:21060799, ECO:0000269|PubMed:24498420}. Note=Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle. {ECO:0000269|PubMed:21060799}. |
| Mouse PG classification | NA |
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