| Gene Information | |
|---|---|
| Gene Name | CDHR5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 845 |
| Protein Names | Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein) (Mucin-like protocadherin) (MLPCDH) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000099834 ) 3 ( ENSG00000273572 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9HBB8 |
| Gene Card | CDHR5 |
| Uniprot ID | Q9HBB8 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.653180502) |
| Ortholog in Animals | Alpaca_ CDHR5 ( ortholog_one2one ) GuineaPig_ CDHR5 ( ortholog_one2one ) Macaque_ CDHR5 ( ortholog_one2one ) Mouse_ Cdhr5 ( ortholog_one2one ) Pig_ CDHR5 ( ortholog_one2one ) Rat_ Cdhr5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDH1, CDHR2, CDH22, CDH5, CDH2 |
| Tissue | duodenum, small.intestine, colon, gall.bladder, kidney, small.intestine.Peyers.patch |
| Tissue Specificity | Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409). {ECO:0000269|PubMed:12167596, ECO:0000269|PubMed:24725409}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6OAE (X-ray 1.90A ) |
| DBSNP | rs2740374 rs2246614 rs2306066 rs2740375 rs2740379 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. |
| Mouse PG classification | NA |
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