| Gene Information | |
|---|---|
| Gene Name | CHI3L1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 383 |
| Protein Names | Chitinase-3-like protein 1 (39 kDa synovial protein) (Cartilage glycoprotein 39) (CGP-39) (GP-39) (hCGP-39) (YKL-40) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000133048 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P36222 |
| Gene Card | CHI3L1 |
| Uniprot ID | P36222 |
| Pfam | PF00704 |
| In ASD | no |
| Allosteric Prediction | yes (0.328034054) |
| Ortholog in Animals | Alpaca_ CHI3L1 ( ortholog_one2one ) Dog_ CHI3L1 ( ortholog_one2one ) GuineaPig_ CHI3L1 ( ortholog_one2one ) Macaque_ CHI3L1 ( ortholog_one2one ) Mouse_ Chil1 ( ortholog_one2one ) Pig_ CHI3L1 ( ortholog_one2one ) Rat_ Chi3l1 ( ortholog_one2one ) Rabbit_ CHI3L1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CHIA, CHID1, CHIT1, CTBS, OVGP1, CHI3L2 |
| Tissue | NA |
| Tissue Specificity | Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:9492324}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1HJV (X-ray 2.75A ) 1HJW (X-ray 2.30A ) 1HJX (X-ray 1.85A ) 1NWR (X-ray 2.70A ) 1NWS (X-ray 2.70A ) 1NWT (X-ray 2.50A ) 1NWU (X-ray 2.20A ) 7CJ2 (X-ray 2.70A ) |
| DBSNP | rs880633 rs1049407 |
| Subcellular location [CC] | Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. |
| Mouse PG classification | LPG |
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