| Gene Information | |
|---|---|
| Gene Name | TM4SF5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 197 |
| Protein Names | Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000142484 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14894 |
| Gene Card | TM4SF5 |
| Uniprot ID | O14894 |
| Pfam | PF05805 |
| In ASD | no |
| Allosteric Prediction | no (-1.119314532) |
| Ortholog in Animals | Alpaca_ TM4SF5 ( ortholog_one2one ) Dog_ TM4SF5 ( ortholog_one2one ) GuineaPig_ TM4SF5 ( ortholog_one2one ) Macaque_ TM4SF5 ( ortholog_one2one ) Mouse_ Tm4sf5 ( ortholog_one2one ) Pig_ TM4SF5 ( ortholog_one2one ) Rat_ Tm4sf5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TM4SF4, TM4SF18, TM4SF1, TM4SF20, TM4SF19 |
| Tissue | duodenum, small.intestine, colon, gall.bladder, liver |
| Tissue Specificity | Intestine. Overexpressed in pancreatic cancers. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. {ECO:0000269|PubMed:30956113}. |
| Mouse PG classification | NA |
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