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Gene Information
Gene Name
SHPTP2
Organism
Homo sapiens (Human)
Gene Length
593
Protein Names
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
Q06124
Gene Card
PTPN11
Uniprot ID
Q06124
Pfam
PF00017; PF00102
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Widely expressed, with highest levels in heart, brain, and skeletal muscle. {ECO:0000269|PubMed:1280823, ECO:0000269|PubMed:7681589, ECO:0000269|PubMed:8216283}.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.036735(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
2SHP
(X-ray
2.00A
)
3B7O
(X-ray
1.60A
)
3MOW
(X-ray
2.30A
)
3O5X
(X-ray
2.00A
)
3TKZ
(X-ray
1.80A
)
3TL0
(X-ray
2.05A
)
3ZM0
(X-ray
1.50A
)
3ZM1
(X-ray
1.40A
)
3ZM2
(X-ray
1.50A
)
3ZM3
(X-ray
1.50A
)
4DGP
(X-ray
2.30A
)
4DGX
(X-ray
2.30A
)
4GWF
(X-ray
2.10A
)
4H1O
(X-ray
2.20A
)
4H34
(X-ray
2.70A
)
4JE4
(X-ray
2.31A
)
4JEG
(X-ray
2.30A
)
4JMG
(X-ray
1.40A
)
4NWF
(X-ray
2.10A
)
4NWG
(X-ray
2.45A
)
4OHD
(X-ray
2.70A
)
4OHE
(X-ray
2.51A
)
4OHH
(X-ray
2.70A
)
4OHI
(X-ray
2.20A
)
4OHL
(X-ray
2.40A
)
4PVG
(X-ray
2.40A
)
4QSY
(X-ray
2.10A
)
4RDD
(X-ray
1.60A
)
5BK8
(X-ray
2.25A
)
5DF6
(X-ray
1.78A
)
5EHP
(X-ray
1.85A
)
5EHR
(X-ray
1.70A
)
5I6V
(X-ray
1.87A
)
5IBM
(X-ray
2.18A
)
5IBS
(X-ray
2.32A
)
5X7B
(X-ray
2.45A
)
5X94
(X-ray
2.60A
)
5XZR
(X-ray
2.80A
)
6ATD
(X-ray
2.50A
)
6BMR
(X-ray
2.21A
)
6BMU
(X-ray
2.12A
)
6BMV
(X-ray
2.05A
)
6BMW
(X-ray
2.10A
)
6BMX
(X-ray
2.42A
)
6BMY
(X-ray
2.09A
)
6BN5
(X-ray
2.22A
)
6CMP
(X-ray
1.80A
)
6CMQ
(X-ray
2.90A
)
6CMR
(X-ray
2.21A
)
6CMS
(X-ray
2.68A
)
6CRF
(X-ray
2.62A
)
6CRG
(X-ray
2.75A
)
6MD7
(X-ray
1.96A
)
6MD9
(X-ray
2.12A
)
6MDA
(X-ray
2.21A
)
6MDB
(X-ray
2.34A
)
6MDC
(X-ray
2.14A
)
6MDD
(X-ray
2.05A
)
6R5G
(NMR
-
)
6WU8
(X-ray
2.40A
)
7EMN
(X-ray
3.00A
)
7JVM
(X-ray
2.17A
)
7JVN
(X-ray
1.92A
)
7R75
(X-ray
2.83A
)
7R7D
(X-ray
2.60A
)
7R7I
(X-ray
2.85A
)
7R7L
(X-ray
3.00A
)
7RCT
(X-ray
1.80A
)
7VXG
(X-ray
2.10A
)
DBSNP
rs267606990
rs397507501
rs397507506
rs886043790
rs397507509
rs397507509
rs121918461
rs397507510
rs121918461
rs397507510
rs121918460
rs121918459
rs397507511
rs397507511
rs397507512
rs121918454
rs121918453
rs121918453
rs121918454
rs121918462
rs121918465
rs397507514
rs121918465
rs121918464
rs121918465
rs121918466
rs397507517
rs397507520
rs397507523
rs397507525
rs765642157
rs397507526
rs376607329
rs121918456
rs121918456
rs397507529
rs397507531
rs121918463
rs28933386
rs121918455
rs201787206
rs121918467
rs121918468
rs121918469
rs121918457
rs397507539
rs397507542
rs397507541
rs397507543
rs121918458
rs397507546
rs397507545
rs397507547
rs397509345
rs397507549
rs121918470
rs397516797
Subcellular location [CC]
Cytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}.
Mouse PG classification
NA
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